Seybold began her career as the first Web editor for the American Society of Clinical Oncology, and soon moved to the National Cancer Institute, where she built a web-based initiative to increase understanding of and participation in cancer clinical trials. While at NCI, Seybold participated in a number of high-level initiatives surrounding the push to develop a unified, branded web presence (now for the Institute.

Seybold spent 16 years consulting to clients in the health information, biomedical, and public health fields as an information architect and user experience practitioner. Clients include several institutes at the National Institutes of Health, the Department of Homeland Security, the Department of Education, Memorial Sloan Kettering, and Johnson & Johnson.

Seybold co-founded the PALTOWN Development Foundation, a 501(c)3 corporation, in 2016. The Foundation develops and manages online support communities for patients and caregivers affected by serious disease.

Seybold holds a B.A. in Humanities and M.A. in Medieval Studies from Yale University.